Multiple Sclerosis and Autoimmune Neurological Disorders Clinic
(A part of the Basil and Farida El-Baz Center for Multiple Sclerosis and Devic’s Disease)
The Multiple Sclerosis and Autoimmune Neurological Disorders Clinic manages a broad category of autoimmune neurological diseases, with specific emphasis on multiple sclerosis. Our approach focuses on ruling out the many conditions that can mimic multiple sclerosis first. Once a diagnosis is confirmed, our care team is trained to provide the full range of services our patients need, including routine screening for cognitive, vision, movement, walking and mental health integrity.
Mahmoud AbdelRazek, MD
Laurel Vuong, MD (Neuro-Ophthalmologist)
Our neurology specialists also work with experts in:
- Neuroimaging/Neuroradiology/Nuclear Medicine
- Occupational therapy
- Physical therapy
- Speech therapy
About Multiple Sclerosis and Autoimmune Neurological Disorders
Autoimmunity refers to one’s own immune system attacking the body’s different tissues and organs, leading to short-term or long-term inflammation and reduced function of these organs.
Types of Autoimmune Neurological Disorders:
Multiple Sclerosis and other demyelinating diseases (like NMO)
Multiple sclerosis (MS) is by far the most common autoimmune neurological condition affecting the brain and spinal cord. MS is most common disease we treat in our clinic.
Multiple sclerosis is a chronic condition characterized by episodes of inflammation of the optic nerves, brain and spinal cord. These episodes, called flares or attacks, remit to a varying degree and recur again over a period of many years. Historically, these flares progressively led to accumulation of disability; but as treatment therapies have advanced dramatically, we are seeing less and less disability.
Neuromyelitis optica (NMO or Devic’s Disease) was originally considered a variant of MS, but we now know that it is a separate disease characterized by the presence of an antibody that attacks the optic nerves and spinal cord. Similar to MS, NMO is also known to cause recurring flares of inflammation, but unlike MS, the location of inflammation is usually in one of the optic nerves or the spinal cord and not the brain.
Neurological Manifestations of Rheumatologic Diseases
Conditions referred to as rheumatologic diseases include lupus, sarcoidosis, rheumatoid arthritis, IgG4-related disease, Sjogren’s syndrome, vasculitis, Behcet’s disease and others. These conditions are considered autoimmune disorders and typically affect organs other than the brain or spinal cords. Rarely, their inflammatory reaction also includes the brain, the spinal cord, their covering membranes (meninges) and the nerves of the arms and legs; this is referred to as their “Neurological Manifestations”. Treatment of such cases requires expertise in this rare field of conditions which our clinic offers. An understanding of these conditions is important as they can mimic multiple sclerosis but are treated very differently.
Autoimmune encephalitis and myelitis
Autoimmune diseases that can affect the brain and spinal cord are vast and diverse. MS is the most common of these, but other conditions include autoimmune encephalitis which results from an antibody attacking the brain or spinal cord. An understanding of these conditions is important as they can mimic multiple sclerosis but are treated very differently. The providers at our clinic are trained to diagnose and treat these diseases.
At our clinic, we monitor objectively for the signs of disease improvement or progression. We screen each patient on a routine basis with:
- Symbol Digit Modality Test (for cognition or mental capacity)
- 9-hole Peg Test (for hand coordination)
- Timed 25-Foot Walk Test (for gait or walking)
- Brain, Cervical Spine, Thoracic Spine MRI (for new MS lesions that don’t produce symptoms and only show on MRI)
We provide all available services for treatment, this includes:
- MS attack prevention: Called “Disease-modifying therapy”. This includes Injectable, Oral and Infusion therapies. The providers in our clinic work with our patients to choose and tailor these therapies to each specific individual, based on their risk profile and potential side effects.
- MS attack relief: Mainly in the form of steroid therapy. Our goal is to avoid needing to use steroid therapy, but this is available in infusion and oral forms when our providers feel this is absolutely necessary.
- Management of MS symptoms: This includes oral treatments and referrals to other specialists if needed for bladder, fatigue, itching, pain and other symptoms that may arise.
- We encourage exercise as it promotes strength, improves mood and reduces MS-related fatigue.
- We encourage a healthy diet of high-fiber and moderation in fat, carb and protein intake. There is not yet an “MS-specific” diet with rigorous evidence.
- Routine screening questionnaires for depression and other mental health issues that may arise in MS are part of our approach.
- Our clinic is geared to ensure and promote strong mental health through drug therapy, counseling, and referral to one of the many mental health providers at Mount Auburn Hospital.
National Multiple Sclerosis Society
Autoimmune Encephalitis Alliance
Americas Committee for Treatment in Multiple Sclerosis
To schedule an appointment with the Multiple Sclerosis and Autoimmune Neurological Disorders Clinic, please call 617-868-0880.